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KMID : 1197720150080020055
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대한파킨슨병 및 이상운동질환 학회지
2015 Volume.8 No. 2 p.55 ~ p.66
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123I-Metaiodobenzylguanidine Myocardial Scintigraphy in Lewy Body-Related Disorders: A Literature Review
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Chung Eun-Joo
Kim Sang-Jin
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Abstract
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Lewy body-related disorders are characterized by the presence of Lewy bodies and Lewy neurites, which have abnormal aggregations of α-synuclein in the nigral and extranigral areas, including in the heart. 123I-metaiodobenzylguanidine (MIBG) scintigraphy is a well-known tool to evaluate cardiac sympathetic denervation in the Lewy body-related disorders. MIBG scintigraphy showed low uptake of MIBG in the Lewy body-related disorders, including Parkinson’s disease, dementia with Lewy bodies, pure autonomic failure and rapid eye movement sleep behavior disorder. This review summarizes previous results on the diagnostic applications of MIBG scintigraphy in Lewy body-related disorders.
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KEYWORD
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123I-metaiodobenzylguanidine scintigraphy, Lewy body-related disorders, Parkinsonism, Dementia
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